Adina-Luminita Milac, Ph.D habil

Biography

Papers

• Manoliu LCE, Martin EC, Milac AL, Spiridon LManoliu LCE et al . "Effective Use of Empirical Data for Virtual Screening against APJR GPCR Receptor", Molecules (Basel, Switzerland) 26(16), (2021)
  IF: 4.41AI: 0.60
• Famiglietti AL, Wei Z, Beres TM, Milac AL, Tran DT, Patel D, Angerer RC, Angerer LM, Tabak LAFamiglietti AL et al . "Characterization and expression analysis of Galnts in developing Strongylocentrotus purpuratus embryos", PloS one 12(4): e0176479, (2017)
  IF: 2.77
• Popa IL, Milac AL, Sima LE, Alexandru PR, Pastrama F, Munteanu CV, Negroiu GPopa IL et al . "Cross-talk between Dopachrome Tautomerase and Caveolin-1 Is Melanoma Cell Phenotype-specific and Potentially Involved in Tumor Progression", The Journal of biological chemistry 291(24): 12481-500, (2016)
  IF: 4.12
• Avram S, Borcan F, Borcan LC, Milac AL, Mihailescu DAvram S et al . "QSAR Approaches Applied to Antidepressants Induced Neurogenesis--in vivo and in silico Applications", Mini reviews in medicinal chemistry 16(3): 230-40, (2015)
  
• Avram S, Milac A, Mernea M, Mihailescu D, Putz MV, Buiu CAvram S et al . "Structure-biological function relationship extended to mitotic arrest-deficient 2-like protein Mad2 native and mutants-new opportunity for genetic disorder control", International journal of molecular sciences 15(11): 21381-400, (2014)
  
• Milac AL, Bojarska E, Wypijewska del Nogal AMilac AL et al . "Decapping Scavenger (DcpS) enzyme: advances in its structure, activity and roles in the cap-dependent mRNA metabolism", Biochimica et biophysica acta 1839(6): 452-62, (2014)
  
• Filimon A, Zurac SA, Milac AL, Sima LE, Petrescu SM, Negroiu GFilimon A et al . "Value of dopachrome tautomerase detection in the assessment of melanocytic tumors", Melanoma research 24(3): 219-36, (2014)
  
• Wypijewska del Nogal A, Surleac MD, Kowalska J, Lukaszewicz M, Jemielity J, Bisaillon M, Darzynkiewicz E, Milac AL, Bojarska EWypijewska del Nogal A et al . "Analysis of decapping scavenger cap complex using modified cap analogs reveals molecular determinants for efficient cap binding", The FEBS journal 280(24): 6508-27, (2013)
  IF: 3.99
• Florian PE, Macovei A, Lazar C, Milac AL, Sokolowska I, Darie CC, Evans RW, Roseanu A, Branza-Nichita NFlorian PE et al . "Characterization of the anti-HBV activity of HLP1-23, a human lactoferrin-derived peptide", Journal of medical virology 85(5): 780-8, (2013)
  IF: 2.22AI: 0.70
• Avram S, Milac AL, Carta F, Supuran CTAvram S et al . "More effective dithiocarbamate derivatives inhibiting carbonic anhydrases, generated by QSAR and computational design", Journal of enzyme inhibition and medicinal chemistry 28(2): 350-9, (2013)
  
• Avram S, Milac AL, Mihailescu DAvram S et al . "3D-QSAR study indicates an enhancing effect of membrane ions on psychiatric drugs targeting serotonin receptor 5-HT1A", Molecular bioSystems 8(5): 1418-25, (2012)
  IF: 3.35AI: 1.20
• Avram S, Buiu C, Borcan F, Milac ALAvram S et al . "More effective antimicrobial mastoparan derivatives, generated by 3D-QSAR-Almond and computational mutagenesis", Molecular bioSystems 8(2): 587-94, (2012)
  
• Milac A, Anishkin A, Fatakia SN, Chow CC, Sukharev S, Guy HRMilac A et al . "Structural models of TREK channels and their gating mechanism", Channels (Austin, Tex.) 5(1): 23-33, (2011)
  
• Maksaev G, Milac A, Anishkin A, Guy HR, Sukharev SMaksaev G et al . "Analyses of gating thermodynamics and effects of deletions in the mechanosensitive channel TREK-1: comparisons with structural models", Channels (Austin, Tex.) 5(1): 34-42, (2011)
  
• Anishkin A, Milac AL, Guy HRAnishkin A et al . "Symmetry-restrained molecular dynamics simulations improve homology models of potassium channels", Proteins 78(4): 932-49, (2010)
  
• Kudla U, Milac AL, Qin L, Overmars H, Roze E, Holterman M, Petrescu AJ, Goverse A, Bakker J, Helder J, Smant GKudla U et al . "Structural and functional characterization of a novel, host penetration-related pectate lyase from the potato cyst nematode Globodera rostochiensis", Molecular plant pathology 8(3): 293-305, (2007)
  
• Milac AL, Buchete NV, Fritz TA, Hummer G, Tabak LAMilac AL et al . "Substrate-induced conformational changes and dynamics of UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase-2", Journal of molecular biology 373(2): 439-51, (2007)
  
• Milac AL, Avram S, Petrescu AJMilac AL et al . "Evaluation of a neural networks QSAR method based on ligand representation using substituent descriptors. Application to HIV-1 protease inhibitors", Journal of molecular graphics & modelling 25(1): 37-45, (2006)
  AI: 0.90
• Jaubert S, Milac AL, Petrescu AJ, de Almeida-Engler J, Abad P, Rosso MNJaubert S et al . "In planta secretion of a calreticulin by migratory and sedentary stages of root-knot nematode", Molecular plant-microbe interactions : MPMI 18(12): 1277-84, (2005)
  
• Costin GE, Valencia JC, Wakamatsu K, Ito S, Solano F, Milac AL, Vieira WD, Yamaguchi Y, Rouzaud F, Petrescu AJ, Lamoreux ML, Hearing VJCostin GE et al . "Mutations in dopachrome tautomerase (Dct) affect eumelanin/pheomelanin synthesis, but do not affect intracellular trafficking of the mutant protein", The Biochemical journal 391(Pt 2): 249-59, (2005)
  
• Kudla U, Qin L, Milac A, Kielak A, Maissen C, Overmars H, Popeijus H, Roze E, Petrescu A, Smant G, Bakker J, Helder JKudla U et al . "Origin, distribution and 3D-modeling of Gr-EXPB1, an expansin from the potato cyst nematode Globodera rostochiensis", FEBS letters 579(11): 2451-7, (2005)
  
• Petrescu AJ, Milac AL, Petrescu SM, Dwek RA, Wormald MRPetrescu AJ et al . "Statistical analysis of the protein environment of N-glycosylation sites: implications for occupancy, structure, and folding", Glycobiology 14(2): 103-14, (2004)
  
• Adina L. Milac, Gabriela Negroiu. "The Multiple Roles of Tyrosinase-Related Protein-2/LDopachrome Tautomerase in Melanoma: Biomarker, Therapeutic Target, and Molecular Driver in Tumor Progression", pp 22-33, Human Skin Cancers: Pathways, Mechanisms, Targets and Treatments, IntechOpen, (2018).
  ISBN: 1789230956
• Surleac MD, Spiridon LN, TacutuR, Milac AL, Petrescu SM, Petrescu AJSurleac MD et al . "Structural Assessment of Glycosylation Sites Database - SAGS – An Overall View on N-Glycosylation", pp 3-20, Glycosilation, InTech, (2012).
  ISBN: 978-953-51-0771-2

Grants