Romanian Academy
Laura-Georgiana Manica, PhD Student
Biography
2016 - present: Ph.D. Student at Institute of Biochemistry of the Romanian Academy;
2016 - 2019: Resident Pharmacist in Pharmaceutical Laboratory at Emercency University Hospital Bucharest;
2011 - 2016: M.Sc. and B.Sc. in Pharmacy at Faculty of Pharmacy, University of Medicine and Pharmacy of Targu-Mures.
Papers
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. "New panel of biomarkers to discriminate between amelanotic and melanotic metastatic melanoma", Frontiers in oncology 12: 1061832, (2023)
doi: doi: 10.3389/fonc.2022.1061832
IF: 5.74AI: 1.15 -
. "EDEM3 Domains Cooperate to Perform Its Overall Cell Functioning", Int. J. Mol. Sci. 4(22): 2172, (2021)
IF: 4.56AI: 0.80
Grants
High-throughput screening platform for small-molecules with anti-inflammatory potential
2020-2022
Acronym: HTS-IL-1β
Budget: 600.000 RON
Project director: Marioara Chiritoiu-Butnaru
This project aims to develop a sensitive high-throughput screening platform by generating an endogenously tagged interleukin-1β reporter cell line by CRISPR-Cas9 technology, able to monitor stimulated IL-1β secretion with the purpose to identify new chemical compounds with anti-inflammatory activity that will be validated in primary macrophages and a mouse model for sepsis.